Original Article

Prediction of Hemodynamic Reactivity during Sevoflurane Remifentanyl Anesthesia for Laparoscopic Cholecystectomy Using Analgesia Nociception Index


  • Ali Şefik Köprülü
  • Mehmet Toptaş
  • Yaşar Gökhan Gül
  • Ali Haspolat
  • Halime Yılmaz
  • Ecder Özenç

Received Date: 05.03.2016 Accepted Date: 23.05.2016 Med Bull Haseki 2016;54(4):212-218


Pneumoperitoneum may cause serious side effects in high-risk patients during laparoscopic cholecystectomy. Perioperative analgesic sufficiency has been measured by the Analgesia Nociception index (ANI) in recent years. We examine the possibility of predicting hemodynamic reactivity by observing sudden changes in ANI during operation.


In this retrospective study, recorded hemodynamic parameters (including heart rate, systolic/ diastolic blood pressure values) and ANI values, before and after intubation, nasogastric tube application, intraperitoneal gas insufflation, and surgical incision in 31 patients who were applied laparoscopic cholecystectomy were compared by paired t-test. Additionally, an increment or decrement of 20% in ANI and 15% in hemodynamic parameters with respect to basal observation values were called “sudden changes”. Correlation of these parameters with sudden changes in ANI values was examined either.


There was a statistically significant difference in parameters after premedication and intubation. After induction, a statistically significant decrement was detected only in heart rate and systolic/diastolic blood pressure values. There was no significant change after nasogastric tube insertion. During pneumoperitoneum and surgical incision, there was no change in heart rate and systolic/diastolic blood pressure values, but a statistically significant decrement was observed in ANI. No correlation was detected between sudden changes in ANI values and hemodynamic parameters.


We assume that use of ANI in analgesia evaluation under general anesthesia at perioperative period is suitable, however, it is not reliable in predicting hemodynamic interaction.

Keywords: Laparoscopic cholecystectomy, Analgesia Nociception index, prediction of hemodynamic reactivity

Full Text (Turkish)